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In this Section
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News & Resources
The INMR has published a wide range of scientific articles. To view a small selection of these articles or to read about us in the popular media, please scroll down or choose an option on the left:
INMR Articles:
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Nature genetics
Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans.
Click here to read more. (330,848bytes) |
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The latest INMR newsletter
Click here to read more. (1,979,813bytes) |
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What are the determinants of athletic ability?
It has long been thought that an individual's genetic code influences their athletic performance. In 2003 Scientists of the INMR published their findings about the role of alpha-actinin 3 in elite sprinting athletes.
Click here to read more. (136,023bytes) |
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Improving the diagnosis of muscular dystrophies.
The INMR team have refined the gold standard for the diagnosis of muscular dystrophies. Diagnosis for the commonly identified muscular dystrophies can now be made using 1 small section (slice) of muscle. This new technique is being adopted by laboratories all over the world.
Click here to read more. (320,265bytes) |
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Nemaline myopathy
Nemaline myopathy is a muscle disease that varies in clinical severity. The INMR team, in conjunction with researchers in Perth and Boston have long studied and identified the specific causes of nemaline myopathy. Using experiments of muscle cells grown in the laboratory, our research team believe they know how the consequences of this muscle disease occur at the cellular level.
Click here to read more. (285,459bytes) |
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a-dystrobrevin and beta2 syntrophin Research
The team in the INMR laboratory have identified a group of patients with severe muscle weakness from birth and who do not have the muscle proteins, a-dystrobrevin and beta2 syntrophin. This is the first group of patients identified with deficiencies of these proteins in the world. Researchers have studied the genes that provide the information for a-dystrobrevin and beta2 syntrophin and have not identified disease causing mutations. They are now concentrating their efforts on proteins that interact with a-dystrobrevin and beta2 syntrophin to identify the specific cause of muscle disease in these patients.
Click here to read more. (4,640,361bytes) |
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INMR in the News:
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The Champion Gene
The INMR research team in conjunction with collaborators at the Australian Institute of Sport, John Curtin School and Harvard University have identified a muscle protein, that is absent in 20% of the healthy population, α actinin 3. Furthermore, a significantly greater proportion of elite sprint athletes have this protein which may suggest that α actinin 3 may play a role in these athletes to produce forceful contractions at high velocity. In 2004, with international media attendion on the Athens Olympics, our researchers made front page of the Bulletin magazine.Click here to read more. (219,907bytes) |
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Our Research in the Headlines
A media frenzy followed with our research of the genetics of athletic ability featured in New Scientist, Wired, Guardian (UK) and was rated within the top 100 science stories of 2003 in Discover magazine, the magazine for Scientist in the know! Click here to read more or Click here to read more. (878,288bytes) |
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Muscle news around the world
A new Institute for Neuromuscular Research in Sydney, Australia.Click here to read more. (41,486bytes) |
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Useful links:
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The Children's Hospital at Westmead
The official web-site for the Children's Hospital at Westmead.
http://www.chw.edu.au |
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PubMed - Articles Written by the INMR Team
A link to articles produced by the INMR team. The index contains abstracts, citations and summaries. Links are shown where the full text of the articles is available online.
Click here to view listing. |
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